By Horace W. Davenport
This booklet examines the heritage of experimental research in gastric secretion and digestion. the writer identifies the clinical questions that experience occupied researchers and discusses the experiments that experience resulted in their strategies. by way of separating facets of experimental research and tracing their evolution through the years, the booklet offers gastric physiologists and gastroenterologists with an effective figuring out of the highbrow historical past in their box.
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Extra resources for A History of Gastric Secretion and Digestion: Experimental Studies to 1975
SECRETION OF HYDROCHLORIC ACID / 39 Carbonic Anhydrase and Sulfanilamide One Sunday morning it occurred to Thaddeus Mann, who tagether with David Keilin had discovered the presence ofzinc in carbonic anhydrase, 109 tbat tbe effects on electrolyte excretion that some clinicians bad seen in patients given large doses of sulfanilamide could be explained if sulfanilamide inhibits carbonic anbydrase. Mann hurried to tbe Iabaratory and found tbat bis deduction was correct; sulfanilamide is a powerful inbibitor of carbonic anhydrase.
Gastric juice is the fluid contained in the glass tube in Figure 1-9 and is separated from the external fluid by a semipermeable membrane. Acid having a concentration of 162 mN, the "primary acidity," is continuously added at the "secretion" rate. Fluid in the tube is sampled and analyzed. Above: the external fluid is 162 mN NaCI. The curves marked (2x) and (4x) are those that would describe the concentration of hydrogen ions if the permeability constant of the membrane were two or four times greater.
Before I got very far, I received a Ietter from R. B. Fisher, my form er Supervisor at Oxford, proposing exactly the same experiment for exactly the same reason, the idea having come to him while invigilating Final Honour Schools examinations. Furthermore, Fisher said that ifbromide and chloride merely follow hydrogen ions on account ofthe potential established by the positive charges on the hydrogen ion, 26 / A HISTORY OF GASTRIC SECRETION AND DIGESTION their rates of entry into gastric juice should be proportional to their concentrations in plasma multiplied by their mobilities in water.